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1

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Karran, Eric, Mercken, Marc, Strooper, Bart De

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 931 KB

english, 2011

2

Alzheimer's disease

Scheltens, Philip, Blennow, Kaj, Breteler, Monique M B, de Strooper, Bart, Frisoni, Giovanni B, Salloway, Stephen, Van der Flier, Wiesje Maria

Journal:

Year:

2016

Language:

english

File:

PDF, 321 KB

english, 2016

3

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, Iryna, Karran, Eric, De Strooper, Bart

Journal:

Nature Neuroscience

Year:

2012

Language:

english

File:

PDF, 544 KB

english, 2012

4

Drosophila transgenic RNAi screen of genes implicated in human neurological disease

Dominik M. Haddad⁎, Melissa Vos, Vanessa A. Morais, Maarten Leyssen, Joke Allemeersch, Bart De Strooper, Patrik Verstreken

Journal:

Year:

2011

Language:

english

File:

PDF, 64 KB

english, 2011

5

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

Arranz, Amaia M, De Strooper, Bart

Journal:

The Lancet Neurology

Year:

2019

Language:

english

File:

PDF, 473 KB

english, 2019

6

The World of Dementia Beyond 2020

Henry Brodaty, Monique M. B. Breteler, Steven T. DeKosky, Pascale Dorenlot, Laura Fratiglioni, Christoph Hock, Paul-Ariel Kenigsberg, Philip Scheltens, Bart De Strooper

Journal:

Journal of the American Geriatrics Society

Year:

2011

Language:

english

File:

PDF, 76 KB

english, 2011

7

10.1038/19083

De Strooper, Bart, Kopan, Raphael, Annaert, Wim, Cupers, Philippe, Saftig, Paul, Craessaerts, Katleen, Mumm, Jeffrey S., Schroeter, Eric H., Schrijvers, Vincent, Wolfe, Michael S., Ray, William J., Go

Journal:

Year:

1999

Language:

english

File:

PDF, 543 KB

english, 1999

8

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Bruno Bergmans, Aikaterini S. Papadopoulou, André Delacourte, Bart De Strooper

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 756 KB

english, 2009

9

Non-coding RNAs with essential roles in neurodegenerative disorders

Evgenia Salta, Bart De Strooper

Journal:

The Lancet Neurology

Year:

2012

Language:

english

File:

PDF, 605 KB

english, 2012

10

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, Ilya Bezprozvanny

Journal:

Year:

2006

Language:

english

File:

PDF, 957 KB

english, 2006

11

Gene Dosage Effect on γ-Secretase Component Aph-1b in a Rat Model for Neurodevelopmental Disorders

Marcel W. Coolen, Karen M.J. Van Loo, Nick N.H.M. Van Bakel, David J. Pulford, Lutgarde Serneels, Bart De Strooper, Bart A. Ellenbroek, Alexander R. Cools, Gerard J.M. Martens

Journal:

Year:

2005

Language:

english

File:

PDF, 325 KB

english, 2005

12

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

Bart De Strooper

Journal:

Year:

2003

Language:

english

File:

PDF, 65 KB

english, 2003

13

Tudca, a bile acid, attenuates amyloid beta deposition and rescues memory deficits in app/ps1 mice

Nunes, Ana, Fonseca, Maria, Viana, Ricardo, Lo, Adrian, De Strooper, Bart, D'Hooge, Rudi, Rodrigues, Cecília

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 73 KB

english, 2011

14

Cholesterol Depletion Inhibits the Generation of β -amyloid in Hippocampal Neurons

Mikael Simons, Patrick Keller, Bart De Strooper, Konrad Beyreuther, Carlos G. Dotti and Kai Simons

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.24 MB

english, 1998

15

Lessons from a Failed γ-Secretase Alzheimer Trial

De Strooper, Bart

Journal:

Year:

2014

Language:

english

File:

PDF, 666 KB

english, 2014

16

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

De Strooper, Bart, Chávez Gutiérrez, Lucía

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 793 KB

english, 2015

17

Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites

Ferjentsik, Zoltan, Hayashi, Shinichi, Dale, J. Kim, Bessho, Yasumasa, Herreman, An, De Strooper, Bart, del Monte, Gonzalo, de la Pompa, Jose Luis, Maroto, Miguel, Henry, Clarissa A.

Journal:

Year:

2009

Language:

english

File:

PDF, 4.80 MB

english, 2009

18

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart

Journal:

EMBO Molecular Medicine

Year:

2017

Language:

english

File:

PDF, 5.90 MB

english, 2017

19

Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems

Salas, Isabel H., De Strooper, Bart

Journal:

Neurochemical Research

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

20

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Rice, Heather C., Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L., Müller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart

Journal:

Molecular Neurodegeneration

Year:

2020

Language:

english

File:

PDF, 2.38 MB

english, 2020

21

Cancer and neurodegeneration meet

Bart De Strooper

Journal:

EMBO Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 78 KB

english, 2010

22

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

Iryna Benilova, Bart De Strooper

Journal:

EMBO Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 185 KB

english, 2010

23

Notch pathway is dispensable for adipocyte specification

Amy M. Nichols, Yonghua Pan, An Herreman, Brandon K. Hadland, Bart De Strooper, Raphael Kopan, Stacey S. Huppert

Journal:

Year:

2004

Language:

english

File:

PDF, 299 KB

english, 2004

24

α2-macroglobulin and subacute-phase responses in Alzheimer's disease

Bart De Strooper, Fred Van Leuven

Journal:

Immunology Today

Year:

1993

Language:

english

File:

PDF, 134 KB

english, 1993

25

The amyloid precursor protein (APP)-cytoplasmic fragment generated by γ-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

Philippe Cupers, Isabelle Orlans, Katleen Craessaerts, Wim Annaert, Bart De Strooper

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 675 KB

english, 2001

26

Gene profiling of hippocampal neuronal culture

Michal Dabrowski, Stein Aerts, Paul Van Hummelen, Katleen Craessaerts, Bart De Moor, Wim Annaert, Yves Moreau, Bart De Strooper

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 314 KB

english, 2003

27

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion proteinin vivo

Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel

Journal:

Molecular Neurodegeneration

Year:

2011

Language:

english

File:

PDF, 4.17 MB

english, 2011

28

Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation

Bruno A. Bergmans, S. Ali M. Shariati, Ron L.P. Habets, Patrik Verstreken, Luc Schoonjans, Ulrike Müller, Carlos G. Dotti, Bart De Strooper

Journal:

Year:

2010

Language:

english

File:

PDF, 849 KB

english, 2010

29

Conserved residues within the putative active site of γ-secretase differentially influence enzyme activity and inhibitor binding

Jonathan D. J. Wrigley, Emma J. Nunn, Omar Nyabi, Earl E. Clarke, Peter Hunt, Alan Nadin, Bart De Strooper, Mark S. Shearman, Dirk Beher

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 205 KB

english, 2004

30

Presenilin clinical mutations can affect γ-secretase activity by different mechanisms

Mostafa Bentahir, Omar Nyabi, Jan Verhamme, Alexandra Tolia, Katrien Horré, Jens Wiltfang, Hermann Esselmann, Bart De Strooper

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 771 KB

english, 2006

31

The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing

Sabine Rabe, Julia Reichwald, Domenico Ammaturo, Bart de Strooper, Paul Saftig, Ulf Neumann, Matthias Staufenbiel

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 272 KB

english, 2011

32

Alterations in phosphatidylethanolamine levels affect the generation of Aβ

Iva Nesic, Francesc X. Guix, Krist’l Vennekens, Vasiliki Michaki, Paul P. Van Veldhoven, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti, Tina Wahle

Journal:

Year:

2012

Language:

english

File:

PDF, 697 KB

english, 2012

33

Neuropathology and Neurodegeneration in Rodent Brain Induced by Lentiviral Vectormediated Overexpression of α-Synuclein

Erwin Lauwers, Zeger Debyser, Jo Van Dorpe, Bart De Strooper, Bart Nuttin, Veerle Baekelandt

Journal:

Brain Pathology

Year:

2003

Language:

english

File:

PDF, 720 KB

english, 2003

34

10.1038/34910

De Strooper, Bart, Saftig, Paul, Craessaerts, Katleen, Vanderstichele, Hugo, Guhde, Gundula, Annaert, Wim, Von Figura, Kurt, Van Leuven, Fred

Journal:

Year:

1998

Language:

english

File:

PDF, 382 KB

english, 1998

35

10.1038/35015193

De Strooper, Bart

Journal:

Year:

2000

Language:

english

File:

PDF, 110 KB

english, 2000

36

10.1038/35017105

De Strooper, Bart, Herreman, An, Serneels, Lutgarde, Annaert, Wim, Collen, Desiré, Schoonjans, Luc

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 176 KB

english, 2000

37

Alzheimer's disease: An inflammatory drug prospect

De Strooper, Bart, König, Gerhard

Journal:

Year:

2001

Language:

english

File:

PDF, 115 KB

english, 2001

38

Alzheimer's disease: Mental plaque removal

De Strooper, Bart, Woodgett, James

Journal:

Year:

2003

Language:

english

File:

PDF, 271 KB

english, 2003

39

10.1038/44973

De Strooper, Bart, König, Gerhard

Journal:

Year:

1999

Language:

english

File:

PDF, 187 KB

english, 1999

40

Alzheimer's dementia by circulation disorders: when trees hide the forest

Dotti, Carlos G., Strooper, Bart De

Journal:

Nature Cell Biology

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

41

No endogenous Aβ production in presenilin-deficient fibroblasts

Nyabi, Omar, Pype, Stefan, Mercken, Marc, Herreman, An, Saftig, Paul, Craessaerts, Katleen, Serneels, Lutgarde, Annaert, Wim, De Strooper, Bart

Journal:

Nature Cell Biology

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

42

10.1038/ncb1001-e221

Strooper, Bart De, Annaert, Wim

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 1.04 MB

english, 2001

43

Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

Grimm, Marcus O. W., Grimm, Heike S., Pätzold, Andreas J., Zinser, Eva G., Halonen, Riikka, Duering, Marco, Tschäpe, Jakob-A., Strooper, Bart De, Müller, Ulrike, Shen, Jie

Journal:

Nature Cell Biology

Year:

2005

Language:

english

File:

PDF, 298 KB

english, 2005

44

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

Thathiah, Amantha, De Strooper, Bart

Journal:

Nature Reviews Neuroscience

Year:

2011

Language:

english

File:

PDF, 558 KB

english, 2011

45

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

Reiss, Karina, Maretzky, Thorsten, Ludwig, Andreas, Tousseyn, Thomas, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

46

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling

Reiss, Karina, Maretzky, Thorsten, Ludwig, Andreas, Tousseyn, Thomas, de Strooper, Bart, Hartmann, Dieter, Saftig, Paul

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 38 KB

english, 2005

47

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

Leyssen, Maarten, Ayaz, Derya, Hébert, Sébastien S, Reeve, Simon, De Strooper, Bart, Hassan, Bassem A

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 720 KB

english, 2005

48

The amyloid-β precursor protein: integrating structure with biological function

Reinhard, Constanze, Hébert, Sébastien S, De Strooper, Bart

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 256 KB

english, 2005

49

Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice

Van Gelder, Patrick, Hartmann, Dieter, D'Hooge, Rudi, De Strooper, Bart, Martins, Ivo Cristiano, Kuperstein, Inna, Wilkinson, Hannah, Maes, Elke, Vanbrabant, Mieke, Jonckheere, Wim

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 480 KB

english, 2007

50

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

Hébert, Sébastien S, Serneels, Lutgarde, Tolia, Alexandra, Craessaerts, Katleen, Derks, Carmen, Filippov, Mikhail A, Müller, Ulrike, De Strooper, Bart

Journal:

Year:

2006

Language:

english

File:

PDF, 204 KB

english, 2006